http://www.dagstuhl.de/18082

February 18 – 23 , 2018, Dagstuhl Seminar 18082

Formal Methods for the Synthesis of Biomolecular Circuits

Organizers

Yaakov Benenson (ETH Zürich – Basel, CH)
Neil Dalchau (Microsoft Research UK – Cambridge, GB)
Heinz Koeppl (TU Darmstadt, DE)
Oded Maler (VERIMAG – Grenoble, FR)

For support, please contact

Simone Schilke for administrative matters

Andreas Dolzmann for scientific matters

Documents

Dagstuhl Seminar Schedule (Upload here)

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Motivation

Synthetic biology aims for the rational bottom-up engineering of new biological functionalities. Recent years have witnessed an increase in the degree of "rationality" in the design of synthetic biomolecular circuits. With it, fewer design-build-test cycles are now required to achieve a desired circuit performance. Most of these success stories reported the realization of logic circuits, typically operating via regulation of gene expression and/or direct manipulation of DNA sequences with recombinases, executing combinatorial and sometimes sequential logic. This was achieved with the help of two types of resources: libraries of previously well-characterized genetic components and mechanistic or machine learning-based predictive computational modeling. Hence, although circuits in synthetic biology are still by far less understood and characterized than electronic circuits, the opportunity for the formal synthesis of circuit designs with respect to a behavioral specification starts to emerge in synthetic biology.

This Dagstuhl Seminar will bring together experts in formal methods for the verification and synthesis of hardware and software with wet-lab and dry-lab synthetic biologists to (1) achieve a common understanding of the current state of design methodology in synthetic biology; (2) to identify the limitations of current approaches; and (3) to investigate dedicated solutions to the synthesis problem in synthetic biology. Some of these methods will be based on leveraging experience and methods from cyber-physical systems design, electronic design automation and from program synthesis and verification. In addition, ideas for entirely new methodologies specifically tailored for synthetic biology are likely to emerge. For example, features that are less pronounced in electronic circuits such as heterogeneity and variability between cells and between the circuits embedded in different cells, will be addressed.

License
  Creative Commons BY 3.0 DE
  Yaakov Benenson, Neil Dalchau, Heinz Koeppl, and Oded Maler

Classification

  • Bioinformatics
  • Modelling / Simulation
  • Semantics / Formal Methods

Keywords

  • Synthetic biology
  • Electronic design automation
  • Program synthesis and verification

Book exhibition

Books from the participants of the current Seminar 

Book exhibition in the library, ground floor, during the seminar week.

Documentation

In the series Dagstuhl Reports each Dagstuhl Seminar and Dagstuhl Perspectives Workshop is documented. The seminar organizers, in cooperation with the collector, prepare a report that includes contributions from the participants' talks together with a summary of the seminar.

 

Download overview leaflet (PDF).

Publications

Furthermore, a comprehensive peer-reviewed collection of research papers can be published in the series Dagstuhl Follow-Ups.

Dagstuhl's Impact

Please inform us when a publication was published as a result from your seminar. These publications are listed in the category Dagstuhl's Impact and are presented on a special shelf on the ground floor of the library.

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