http://www.dagstuhl.de/12462

November 11 – 16 , 2012, Dagstuhl Seminar 12462

Symbolic Methods for Chemical Reaction Networks

Organizers

Francois Boulier (University of Lille I, FR)
Anne J. Shiu (University of Chicago, US)
Thomas Sturm (MPI für Informatik – Saarbrücken, DE)
Andreas Weber (Universität Bonn, DE)

For support, please contact

Dagstuhl Service Team

Documents

Dagstuhl Report, Volume 2, Issue 11 Dagstuhl Report
List of Participants
Shared Documents
Dagstuhl's Impact: Documents available
Dagstuhl Seminar Schedule [pdf]

Summary

Systems of differential equations and hybrid systems more generally are prevalent in chemical engineering and systems biology. The analysis of such systems focuses on resolving their dynamical properties, for instance, determining their equilibria and capacity for multistationarity or Hopf bifurcations. The additional tasks of parameter estimation, model reduction, and model inference are also relevant for these systems. These goals are difficult in general, especially due to the large size of these systems, especially those arising in systems biology. Non-numeric methods are essential in this context, because reaction parameters can vary over a wide range, parameter uncertainty is predominant in systems biology, and even the qualitative behavior of a system typically varies among different regions of the parameter space. Two major lines of research in this area are represented by chemical reaction network theory and stoichiometric network analysis. Our Dagstuhl seminar brought together researchers from both of these research areas, as well as researchers in symbolic computation and those on the application side (chemical engineering and systems biology). The aim of our seminar was twofold: to introduce practitioners to existing relevant theory and software from symbolic computation, and to allow participants to pose current computational challenges in this area, in order to spur development of symbolic computation methods to resolve these problems. To this end, collaborative working groups on various related topics were held throughout the week.

Classification

  • Bioinformatics
  • Modelling / Simulation
  • Verification / Logic

Keywords

  • Symbolic computation
  • Chemical reaction network theory
  • Stoichiometric network analysis
  • Qualitative analysis
  • Regulatory interactions

Book exhibition

Books from the participants of the current Seminar 

Book exhibition in the library, ground floor, during the seminar week.

Documentation

In the series Dagstuhl Reports each Dagstuhl Seminar and Dagstuhl Perspectives Workshop is documented. The seminar organizers, in cooperation with the collector, prepare a report that includes contributions from the participants' talks together with a summary of the seminar.

 

Download overview leaflet (PDF).

Publications

Furthermore, a comprehensive peer-reviewed collection of research papers can be published in the series Dagstuhl Follow-Ups.

Dagstuhl's Impact

Please inform us when a publication was published as a result from your seminar. These publications are listed in the category Dagstuhl's Impact and are presented on a special shelf on the ground floor of the library.

NSF young researcher support